General Information

  • ID:  hor002539
  • Uniprot ID:  NA
  • Protein name:  leech osmoregulatory factor
  • Gene name:  NA
  • Organism:  Theromyzon tessulatum
  • Family:  NA
  • Source:  animal
  • Expression:  CNS
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  IPEPYVWD
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Action on the hydric balance
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002539_AF2.pdbhor002539_ESM.pdb

Physical Information

Mass: 114317 Formula: C50H67N9O14
Absent amino acids: ACFGHKLMNQRST Common amino acids: P
pI: 3.55 Basic residues: 0
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: -46.25 Boman Index: -438
Half-Life: 20 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 85
Instability Index: 5095 Extinction Coefficient cystines: 6990
Absorbance 280nm: 998.57

Literature

  • PubMed ID:  9037546
  • Title:  Structural Characterization of Osmoregulator Peptides From the Brain of the Leech Theromyzon Tessulatum: IPEPYVWD and IPEPYVWD-amide